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KMID : 0882419930440040520
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Korean Journal of Medicine
1993 Volume.44 No. 4 p.520 ~ p.529
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Effects of Weight Loss on Glucose and Lipid Metabolism in Obese Individuals
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허갑범
정윤석/박석원/이현철/임승길/이영해/이종호/백인경/박유경
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Abstract
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ackground : The purpose of obseity treatment is to attain optimal body weight and to
maintain weight loss. We determined the effects of weight loss with a program including
dietary eduction, exercise and behavioral modification of lifestyle on obese subjects.
Methods ; Middle-aged obse women (n=30) and men (n=9) participated in a 6-month
weight-management program. Anthropometric parameters and visceral and subcutaneous fat
areas at the umbilical level were determined before and after weiht loss. Serum levels of
lipids and response areas of glucose, C-peptide, insulin and free fatty acid (FFA) during oral
glucose tolerance test were determined.
Results ; Body weight fell an average of 3.9kg (6.3%) in women and 4.1%(5.4%) in men.
Modest weight loss showed a 23 to 48% decrease in the levels of serum LDL and total
colesterol and a 50 to 130% increase in the ratio of HDL to total cholesterol in all subjects.
Although intraabdominal toal fat area of females before weight loss was not different from
males, females showed subcutaneous-type obesity and males visceraltype obestiy. Compared
with females, males before weight loss showed an increase in the lefvesl of triglyceride, FFA
and insulin. Although weight loss caused a decrease in intraabdominal total fat area in all
subjects, a significant decrease in visceral fat area was only shown in men. Decreased
visceral fat in males lowered Ffa level and decreased FFA level lowered serum triglyceride
leve (49%) and response are of insulin (56%) inmen.
Conclusion ; The results suggest that modest weight reduction through a weight
management program can be a viable approach to help normalize plasma lipids and
lipoporteins in obse individuals. Modest and gradual weight loss can also help obese
individuals succeed in the difficult task of losing weight and maintaining this substantial
weight loss.
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KEYWORD
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